ShinBi: Diclofenac isn’t just for arthritis

Diclofenac is usually given for arthritis, but that’s not the only usage. Diflofenic is a nonsteroidal anti-inflammatory drug according to Drugs.com. It reduces substances in the body that cause pain and inflammation for for that reason is used for arthritis or ankylosing spondylitis.

It can also be used to treat migraine headaches but not to treat cluster headaches.

We don’t know if our sweet ShinBi had headaches, but he does have problems with his eyes.

This is a drug with serious side effects and should only be used under prescription from a doctor or veterinarian.

It is useful in lens-induced uveitis in dogs and may be a pre-operative and postoperative agent for uveitis associated with eye surgery. Now you ask what is uveitis? Uveitis is the escape of lens proteins into the eye fluid that is most frequently associated with cataracts.

Cataracts begin as a cloudy or dull appearance in the front of the eye and then the iris becomes unevenly colored with yellow or white areas. About 75 percent of dogs with diabetes develop cataracts within nine months of being diagnoses.

If the lens-induced uveitis goes untreated and glaucoma also develops, cataract surgery might not be possible. Glaucoma causes chronic headaches.

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AHS: Recommended Management Protocol

ShinBi healthcare schedule:

28 February 2014

28 March 2014

14 March 2014

  • Minor re-check exam ($22.50)
  • Glucose Curve  ($65.79)

28 March 2015

  • Minor re-check exam ($22.50)
  • Glucose Curve  ($65.79)

11 April 2014

  • Minor re-check exam ($22.50)
  • Glucose Curve  ($65.79)

25 April 2014

  • Minor re-check exam ($22.50)
  • Glucose Curve  ($65.79)

28 April 2014

9 May 2014

  • Minor re-check exam ($22.50)
  • Glucose Curve  ($65.79)

23 May 2014

  • Minor re-check exam ($22.50)
  • Glucose Curve  ($65.79)

28 May 2014

29 May

28 August 2014

  • Test for microfilariae–If positive, then treat with microfilaricide and re-test in 4 weeks
  • Establish year-round heartworm prevention

February 2015

  • Antigen test six months after completion

PROJECTED COST FOR DIABETES  (MARCH-AUGUST 2014)

  • Minor re-check exam ($22.50) twice a week for six months  = $270
  • Glucose Curve  ($65.79) twice a week for six months = $789.48
  • Insulin ($42) once a month for six months = $252
  • Insulin Syringe ($33.60) once a month for six months  = $201.60

SUBTOTAL =  $1513.08

PROJECTED COST FOR HEARTWORM TREATMENT

SUBTOTAL = $474.79

TOTAL PROJECTED COST = $1987.87

If you’d like to help Southland Collie Rescue cover the costs of ShinBi’s care, you can:

Donate directly by sending a check to:

  • Southland Collie Rescue 
  • P.O. Box 1596
  • Brea, CA 92822-1596
  • Instruct that the donation is for ShinBi

You can donate through Just Give.

You can donate through the GoFundMe page.

Treatment: Prednisone

Prednisone is a synthetic corticosteroid drug used to treat inflammation, allergies and complications of chronic illnesses.

The side effects of Prednisone, according to PetMD.com, may include increased drinking and urination, altered behavior, panting, vomiting, diarrhea, ulceration of the digestive tract, lethargy, aggression and delayed healing.

Treatment: Melarsomine injection

ShinBit is receiving a Melarsomine injection to kill the adult heartworms. So Melarsomine is an adulticide and is the Immiticide referred to in the heartworm treatment report.

Remember the adult worms can live in the heart and pulmonary arteries which is why heartworms get their name. Melarsomine is the only medication currently being used to kill adult heartworms. Because it is injected into the muscles of the back, the injections can be painful.

Doxycycline is also used to kill the Wolbachia organism infection that often accompanies heartworm disease.  This organism is thought to also provide some sort of protection for adult heartworms and may cause inflammation in the lungs of the infected animal after the adult heartworms die.

The dying heartworms can cause obstructions in the blood vessels of the lungs. Exercise can increase the risk of an embolism and serious side effects so ShinBi must be kept quiet and inactive during his heartworm treatment.

Treatment: Doxycycline

Doxycycline is an antibiotic used for treatment of a variety of problems. ShinBi is being given this medication for his heartworm.  ShinBi was also positive for Anaplasmosis and Doxycycline is also used to treat this–that’s two for one!

According to PetMed.com, here’s what you need to know:

  • Drug Name: Doxycycline
  • Common Name: Vibramycin®, Doxychel®, Doxy Caps®, Bio-tab®, Monodox®, Doryx®, Doxirobe®
  • Drug Type: Broad spectrum antibiotic
  • Used For: Bacterial infections
  • Species: Dogs, Cats
  • Administered: Tablets, Oral liquid
  • How Dispensed: Prescription only
  • FDA Approved: Yes
  • Recommended Online Pharmacy: Get Doxycycline at Pet360.com

General Description

Doxycycline is a broad spectrum antibiotic that is a member of the tetracycline family. It is used to fight bacterial infections in dogs and cats. Doxycycline is used to treat many different bacterial infections including, leptospirosis, toxoplasmosis, mycoplasma, psittacosis, and tick borne diseases including Lyme disease, ehrlichiosis, and Rocky Mountain spotted fever.

How It Works

Doxycycline binds to specific cell parts (ribosomes) of the bacteria and inhibit the protein synthesis, thus not allowing the bacteria to grow and divide. The process of shutting the protein synthesis down is not rapid. For this reason treatments using Doxycycline are generally termed as a long term treatment. It takes some time after the process is shut down until NSAIDs work by reducing the enzyme COX-2. COX-2. these enzymes are involved in the formation of prostaglandins which cause swellingand inflammation. Reduction of these factors reduce the pain and inflammation your pet experiences.

Treatment: Dexamethasone

ShinBi received a Dexamethasone injection.

PetMD.com explains the usage of Dexamethasone:

Dexamethasone is many times more potent than other anti-inflammatory and immunosuppressing drugs including hydrocortisone and prednisone. It is often mixed with other drugs to treat difficult ear, eye, and skin infections. It reaches every system in the body and therefore is used to treat many disorders:

  • Adrenal insufficiency
  • Rheumatoid arthritis
  • Systemic Lupus
  • Allergies
  • Asthma
  • Dermatologic diseases
  • Hematologic disorders
  • Neoplasia (Tumor growth)
  • Nervous system disease
  • Emergency shock
  • General inflammation
  • Inflammatory bowel disease
  • Nephrotic syndrome

Heartworm treatment: Trifexis

ShinBi is being treated with Trifexis.

According to 1800petmeds.com:

Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections.

Benefits:
Begins killing biting fleas within 30 minutes
Kills fleas before they can lay eggs
Prevents heartworm disease
Treats and controls roundworms, hookworms, and whipworms
Artificial beef flavor made from pork liver and hydrolyzed soy
Easy to administer chewable tablet

How it works:
Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Cautions:
Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting.

Side Effects:

Average Monthly Rate (%) of Dogs With Adverse Reactions
Adverse Reaction Trifexis Chewable Tablets2 Active Control Tablets2
Vomiting 6.13 3.08
Pruritus (itching) 4.00 4.91
Lethargy 2.63 1.54
Diarrhea 2.25 1.54
Dermatitis 1.47 1.45
Skin Reddening 1.37 1.26
Decreased appetite 1.27 1.35
Pinnal Reddening 1.18 0.87